HTLV-1-associated myelopathy/tropical spastic paraparesis accompanied with psoriasis

Akihiro Watanabe, Masakazu Kawajiri, Koji Ikezoe, Manabu Osoegawa, Hiroyuki Murai, Hirofumi Ochi, Takayuki Taniwaki, Jun Ichi Kira

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Two adult females developed HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and psoriasis. Both showed chronic progressive paraparesis and sharply demarcated erythematous scaling plaques on their extremities and trunk. One patient had polymyositis while in the other anti-thyroid antibodies, antinuclear antibodies and SS-A antibody, all autoantibodies, were positive. Both patients were treated by intramuscular injections of interferon-α for 2 to 4 weeks, resulting in amelioration of paraparesis. After the therapy psoriasis and polymyositis markedly improved in one patient without any additional therapy, while in the other simultaneous use of topical corticosteroids was effective. This is the first report to describe occurrences of psoriasis in HAM/TSP patients. Although there are several reports indicating interferon-α induces or exacerbates psoriasis, our experience suggests that psoriasis associated with HAM/TSP can be successfully managed even during interferon-α therapy.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Jun 15 2004

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'HTLV-1-associated myelopathy/tropical spastic paraparesis accompanied with psoriasis'. Together they form a unique fingerprint.

Cite this