HPLC analysis of naturally occurring free d-amino acids in mammals

Yurika Miyoshi; Reiko Koga; Tsubasa Oyama; Hai Han; Kyoko Ueno; Kei Masuyama; Yusuke Itoh; Kenji Hamase

doi:10.1016/j.jpba.2012.01.041

HPLC analysis of naturally occurring free d-amino acids in mammals

Yurika Miyoshi, Reiko Koga, Tsubasa Oyama, Hai Han, Kyoko Ueno, Kei Masuyama, Yusuke Itoh, Kenji Hamase

Molecular Bioinformatics

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

Abstract

d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.

Original language	English
Pages (from-to)	42-49
Number of pages	8
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	69
DOIs	https://doi.org/10.1016/j.jpba.2012.01.041
Publication status	Published - Oct 2012

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmaceutical Science
Drug Discovery
Spectroscopy
Clinical Biochemistry

Access to Document

10.1016/j.jpba.2012.01.041

Cite this

@article{5c10084593ef4a3ca5dc72f7ade3ca3a,

title = "HPLC analysis of naturally occurring free d-amino acids in mammals",

abstract = "d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.",

author = "Yurika Miyoshi and Reiko Koga and Tsubasa Oyama and Hai Han and Kyoko Ueno and Kei Masuyama and Yusuke Itoh and Kenji Hamase",

year = "2012",

month = oct,

doi = "10.1016/j.jpba.2012.01.041",

language = "English",

volume = "69",

pages = "42--49",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

publisher = "Elsevier",

}

TY - JOUR

T1 - HPLC analysis of naturally occurring free d-amino acids in mammals

AU - Miyoshi, Yurika

AU - Koga, Reiko

AU - Oyama, Tsubasa

AU - Han, Hai

AU - Ueno, Kyoko

AU - Masuyama, Kei

AU - Itoh, Yusuke

AU - Hamase, Kenji

PY - 2012/10

Y1 - 2012/10

N2 - d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.

AB - d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=84865075457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865075457&partnerID=8YFLogxK

U2 - 10.1016/j.jpba.2012.01.041

DO - 10.1016/j.jpba.2012.01.041

M3 - Review article

C2 - 22386210

AN - SCOPUS:84865075457

SN - 0731-7085

VL - 69

SP - 42

EP - 49

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

ER -

HPLC analysis of naturally occurring free d-amino acids in mammals

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this