HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma

Hisateru Komatsu; Tomohiro Iguchi; Takaaki Masuda; Masami Ueda; Shinya Kidogami; Yushi Ogawa; Sho Nambara; Kuniaki Sato; Quingjang Hu; Tomoko Saito; Hidenari Hirata; Shotaro Sakimura; Ryutaro Uchi; Naoki Hayashi; Shuhei Ito; Hidetoshi Eguchi; Keishi Sugimachi; Yuichiro Doki; Masaki Mori; Koshi Mimori

HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma

Hisateru Komatsu, Tomohiro Iguchi, Takaaki Masuda, Masami Ueda, Shinya Kidogami, Yushi Ogawa, Sho Nambara, Kuniaki Sato, Quingjang Hu, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Yuichiro Doki, Masaki Mori, Koshi Mimori

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12 Citations (Scopus)

Abstract

Background/Aim: Homeobox B7 (HOXB7) gene is involved in various cellular functions. We investigated the clinical significance of HOXB7 expression in hepatocellular carcinoma (HCC). Materials and Methods: HOXB7 mRNA expression in 103 HCC samples and 58 matched noncancerous liver tissues were examined by quantitative realtime polymerase chain reaction (qRT-PCR). HOXB7 protein expression was also examined by immunohistochemistry. Gene set enrichment analysis (GSEA) was performed using a public dataset. Results: HOXB7 expression was significantly higher in HCC tissues than in liver parenchyma. Ten-year overall survival (OS) and 5-year recurrence-free survival (RFS) of cases with higher HOXB7 expression were significantly poorer than those with lower HOXB7 expression. HOXB7 expression was significantly associated with larger tumor size and higher rate of biliary invasion and constituted an independent prognostic factor for OS by multivariate analysis. These results were supported by GSEA. Conclusion: HOXB7 expression in HCC could be a novel biomarker for long-term prognosis after tumor resection.

Original language	English
Pages (from-to)	2767-2773
Number of pages	7
Journal	Anticancer research
Volume	36
Issue number	6
Publication status	Published - Jun 2016

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Komatsu, H., Iguchi, T., Masuda, T., Ueda, M., Kidogami, S., Ogawa, Y., Nambara, S., Sato, K., Hu, Q., Saito, T., Hirata, H., Sakimura, S., Uchi, R., Hayashi, N., Ito, S., Eguchi, H., Sugimachi, K., Doki, Y., Mori, M., & Mimori, K. (2016). HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma. Anticancer research, 36(6), 2767-2773.

Komatsu, H, Iguchi, T, Masuda, T, Ueda, M, Kidogami, S, Ogawa, Y, Nambara, S, Sato, K, Hu, Q, Saito, T, Hirata, H, Sakimura, S, Uchi, R, Hayashi, N, Ito, S, Eguchi, H, Sugimachi, K, Doki, Y, Mori, M & Mimori, K 2016, 'HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma', Anticancer research, vol. 36, no. 6, pp. 2767-2773.

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title = "HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma",

abstract = "Background/Aim: Homeobox B7 (HOXB7) gene is involved in various cellular functions. We investigated the clinical significance of HOXB7 expression in hepatocellular carcinoma (HCC). Materials and Methods: HOXB7 mRNA expression in 103 HCC samples and 58 matched noncancerous liver tissues were examined by quantitative realtime polymerase chain reaction (qRT-PCR). HOXB7 protein expression was also examined by immunohistochemistry. Gene set enrichment analysis (GSEA) was performed using a public dataset. Results: HOXB7 expression was significantly higher in HCC tissues than in liver parenchyma. Ten-year overall survival (OS) and 5-year recurrence-free survival (RFS) of cases with higher HOXB7 expression were significantly poorer than those with lower HOXB7 expression. HOXB7 expression was significantly associated with larger tumor size and higher rate of biliary invasion and constituted an independent prognostic factor for OS by multivariate analysis. These results were supported by GSEA. Conclusion: HOXB7 expression in HCC could be a novel biomarker for long-term prognosis after tumor resection.",

author = "Hisateru Komatsu and Tomohiro Iguchi and Takaaki Masuda and Masami Ueda and Shinya Kidogami and Yushi Ogawa and Sho Nambara and Kuniaki Sato and Quingjang Hu and Tomoko Saito and Hidenari Hirata and Shotaro Sakimura and Ryutaro Uchi and Naoki Hayashi and Shuhei Ito and Hidetoshi Eguchi and Keishi Sugimachi and Yuichiro Doki and Masaki Mori and Koshi Mimori",

year = "2016",

month = jun,

language = "English",

volume = "36",

pages = "2767--2773",

journal = "Anticancer research",

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T1 - HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma

AU - Komatsu, Hisateru

AU - Iguchi, Tomohiro

AU - Masuda, Takaaki

AU - Ueda, Masami

AU - Kidogami, Shinya

AU - Ogawa, Yushi

AU - Nambara, Sho

AU - Sato, Kuniaki

AU - Hu, Quingjang

AU - Saito, Tomoko

AU - Hirata, Hidenari

AU - Sakimura, Shotaro

AU - Uchi, Ryutaro

AU - Hayashi, Naoki

AU - Ito, Shuhei

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Mimori, Koshi

PY - 2016/6

Y1 - 2016/6

N2 - Background/Aim: Homeobox B7 (HOXB7) gene is involved in various cellular functions. We investigated the clinical significance of HOXB7 expression in hepatocellular carcinoma (HCC). Materials and Methods: HOXB7 mRNA expression in 103 HCC samples and 58 matched noncancerous liver tissues were examined by quantitative realtime polymerase chain reaction (qRT-PCR). HOXB7 protein expression was also examined by immunohistochemistry. Gene set enrichment analysis (GSEA) was performed using a public dataset. Results: HOXB7 expression was significantly higher in HCC tissues than in liver parenchyma. Ten-year overall survival (OS) and 5-year recurrence-free survival (RFS) of cases with higher HOXB7 expression were significantly poorer than those with lower HOXB7 expression. HOXB7 expression was significantly associated with larger tumor size and higher rate of biliary invasion and constituted an independent prognostic factor for OS by multivariate analysis. These results were supported by GSEA. Conclusion: HOXB7 expression in HCC could be a novel biomarker for long-term prognosis after tumor resection.

AB - Background/Aim: Homeobox B7 (HOXB7) gene is involved in various cellular functions. We investigated the clinical significance of HOXB7 expression in hepatocellular carcinoma (HCC). Materials and Methods: HOXB7 mRNA expression in 103 HCC samples and 58 matched noncancerous liver tissues were examined by quantitative realtime polymerase chain reaction (qRT-PCR). HOXB7 protein expression was also examined by immunohistochemistry. Gene set enrichment analysis (GSEA) was performed using a public dataset. Results: HOXB7 expression was significantly higher in HCC tissues than in liver parenchyma. Ten-year overall survival (OS) and 5-year recurrence-free survival (RFS) of cases with higher HOXB7 expression were significantly poorer than those with lower HOXB7 expression. HOXB7 expression was significantly associated with larger tumor size and higher rate of biliary invasion and constituted an independent prognostic factor for OS by multivariate analysis. These results were supported by GSEA. Conclusion: HOXB7 expression in HCC could be a novel biomarker for long-term prognosis after tumor resection.

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HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma

Abstract

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UN SDGs

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