Homeostatic capability of rate-sensitive feedback system: Mathematical model

M. Okamoto, K. Hayashi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We have predicted the mathematical model of rat-sensitive feedback control system and have investigated its homeostatic capability by using computer simulations. The results are summarized as follows. 1) By installing a cyclic enzyme system as feedback control element, we could assume the rate-sensitive feedback system at molecular level. 2) This type of feedback had realistic constant-value control capability for external perturbations. 3) This feedback system was more effective for the exclusion of perturbation than was the concentration-sensitive feedback. 4) A large-loop feedback was more stable for perturbation than was short-loop feedback. 5) In sequential feedback system, every key enzyme sensitive to feedback control had to vary the activity at same time for the system to keep homeostasis.

Original languageEnglish
Pages (from-to)R927-R931
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5
Publication statusPublished - 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)


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