HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese

H. Ito, K. Yamasaki, Y. Kawano, I. Horiuchi, C. Yun, Y. Nishimura, J. Kira

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57 Citations (Scopus)


We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501-DRB5*0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study we found that the frequencies of DPA1*0202 and DPB1*0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P(corr) < 0.05 and 89.1% vs 63.0%, P(corr) < O.O5 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalTissue antigens
Issue number2
Publication statusPublished - 1998

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics


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