HLA and Silicosis in Japan

Koji Honda, Kenji Hirayama, Ikuo Kikuchi, Hiroshi Nagato, Hajime Tamai, Takehiko Sasazuki

Research output: Contribution to journalLetterpeer-review

16 Citations (Scopus)


To the Editor: Ellman and Ball were the first to report that rheumatoid arthritis and lung fibrosis occurred concomitantly.1 Roentgenographically, 5 percent of patients with rheumatoid arthritis had signs of lung fibrosis.2 Silicosis is a lung fibrosis caused by prolonged inhalation of silica dusts, and 3.7 percent of these patients have symptoms of rheumatoid arthritis.3 It has also been reported that silicosis developed more frequently in miners with rheumatoid arthritis than in those without rheumatoid arthritis, after exposure to silica.4 We have already reported that there is a statistical association with the HLA specificities Bw54, DR4, and DRw53 in Japanese.

Original languageEnglish
Pages (from-to)1610
Number of pages1
JournalNew England Journal of Medicine
Issue number24
Publication statusPublished - Dec 15 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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