HLA and Graves’ Disease or Diabetes Mellitus in Japan

T. Sasazuki, Y. Kohno, I. Iwamoto, K. Kosaka, K. Okimoto, H. Maruyama, S. Ishiba, J. Konishi, Y. Takeda, S. Naito

Research output: Contribution to journalLetterpeer-review

22 Citations (Scopus)


To the Editor: A significant increase in the incidence of HLA-B8 and Dw3 has been reported in white patients with several autoimmune diseases, including juvenile-onset diabetes mellitus1 and Graves’ disease.23 Two possibilities to explain this phenomenon have been proposed.4 In the first, these two different organ-specific autoimmune diseases might be associated with the same allele of the same gene, and there might be a common initiating pathogenic event in these diseases; secondly, each of these diseases might be associated with a particular allele of different genes, both of which are in linkage disequilibrium with HLA-B8 and HLA-Dw3. Sasazuki et al.

Original languageEnglish
Pages (from-to)630-631
Number of pages2
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - Mar 16 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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