Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma

Hiroyuki Kuwano, Kohei Sumiyoshi, Mitsuhiro Yasuda, Tadahiro Nozoe, Masayuki Watanabe, Shinji Ohno, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalEuropean Journal of Surgical Oncology
Issue number5
Publication statusPublished - Oct 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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