Histological evaluation of apatite cement containing atelocollagen

Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Hideyuki Takano, Shiho Minamiguchi, Masaru Nagayama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
Journaldental materials journal
Issue number2
Publication statusPublished - Mar 2007

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • General Dentistry


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