TY - JOUR
T1 - Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas
AU - Nakashima, Tadashi
AU - Maehara, Yoshihiko
AU - Kohnoe, Shunji
AU - Hayashi, Itsuroh
AU - Katsuta, Yasaburoh
PY - 1990
Y1 - 1990
N2 - The chemosensitivities of 42 human head and neck squamous cell carcinomas were examined using the in vitro succinate dehydrogenase inhibition (SDI) test. The tumor tissues obtained at surgery or biopsy were exposed to five different antitumor drugs: adriamycin (ADM), cisplatin (CDDP), carboquone (CQ), 5‐fluorouracil (5‐FU), and 1‐hexylcarbamoyl‐5‐fluorouracil (HCFU). The results were analyzed according to the histopathologic degree of differentiation of well, moderately, and poorly differentiated squamous cell carcinoma. The average decrease in succinate dehydrogenase activity was 43.2 /pm 24.9 for ADM, 29.0 /pm 14.2 for CDDP, 32.9 /pm 17.6 for CQ, 64.2 /pm 20.6 for 5‐FU, and 26.8 /pm 16.9 for HCFU. There was a statistically significant difference in the decrease of succinate dehydrogenase activity between well and poorly differentiated squamous cell carcinomas. These data suggest that, for patients with a poorly differentiated squamous cell carcinoma, the response to anticancer drugs may be more satisfactory than in those with a welldifferentiated squamous cell carcinoma.
AB - The chemosensitivities of 42 human head and neck squamous cell carcinomas were examined using the in vitro succinate dehydrogenase inhibition (SDI) test. The tumor tissues obtained at surgery or biopsy were exposed to five different antitumor drugs: adriamycin (ADM), cisplatin (CDDP), carboquone (CQ), 5‐fluorouracil (5‐FU), and 1‐hexylcarbamoyl‐5‐fluorouracil (HCFU). The results were analyzed according to the histopathologic degree of differentiation of well, moderately, and poorly differentiated squamous cell carcinoma. The average decrease in succinate dehydrogenase activity was 43.2 /pm 24.9 for ADM, 29.0 /pm 14.2 for CDDP, 32.9 /pm 17.6 for CQ, 64.2 /pm 20.6 for 5‐FU, and 26.8 /pm 16.9 for HCFU. There was a statistically significant difference in the decrease of succinate dehydrogenase activity between well and poorly differentiated squamous cell carcinomas. These data suggest that, for patients with a poorly differentiated squamous cell carcinoma, the response to anticancer drugs may be more satisfactory than in those with a welldifferentiated squamous cell carcinoma.
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U2 - 10.1002/hed.2880120506
DO - 10.1002/hed.2880120506
M3 - Article
C2 - 2211101
AN - SCOPUS:0025075948
SN - 1043-3074
VL - 12
SP - 406
EP - 410
JO - Head & Neck
JF - Head & Neck
IS - 5
ER -