Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu; Mami Noda; Matomo Nishio; Shigeru Kigoshi

doi:10.1016/0014-2999(87)90442-0

Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu
, Mami Noda
, Matomo Nishio
, Shigeru Kigoshi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H₂-receptors.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	European Journal of Pharmacology
Volume	138
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(87)90442-0
Publication status	Published - Jun 19 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(87)90442-0

Cite this

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title = "Histamine increases the Ca current in guinea-pig ventricular myocytes",

abstract = "Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.",

author = "Ikunobu Muramatsu and Mami Noda and Matomo Nishio and Shigeru Kigoshi",

note = "Funding Information: The authors thank M. Ohara for reading the manuscript and Naomi Yamada for secretarial assistance. Tlus work was supported m part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.",

year = "1987",

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doi = "10.1016/0014-2999(87)90442-0",

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T1 - Histamine increases the Ca current in guinea-pig ventricular myocytes

AU - Muramatsu, Ikunobu

AU - Noda, Mami

AU - Nishio, Matomo

AU - Kigoshi, Shigeru

N1 - Funding Information: The authors thank M. Ohara for reading the manuscript and Naomi Yamada for secretarial assistance. Tlus work was supported m part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.

PY - 1987/6/19

Y1 - 1987/6/19

N2 - Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

AB - Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

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UR - https://www.scopus.com/pages/publications/0023244135#tab=citedBy

U2 - 10.1016/0014-2999(87)90442-0

DO - 10.1016/0014-2999(87)90442-0

M3 - Article

C2 - 2442005

AN - SCOPUS:0023244135

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EP - 272

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Histamine increases the Ca current in guinea-pig ventricular myocytes

Abstract

All Science Journal Classification (ASJC) codes

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