Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu, Mami Noda, Matomo Nishio, Shigeru Kigoshi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2
Publication statusPublished - Jun 19 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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