Highly sensitive magnetic nanoparticle imaging using cooled-Cu/HTS- superconductor pickup coils

Takafumi Morishige, Takuro Mihaya, Shi Bai, Takashi Miyazaki, Takashi Yoshida, Masaaki Matsuo, Keiji Enpuku

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


We developed a highly sensitive measurement system of ac magnetic fields for magnetic nanoparticle imaging (MPI). First, we developed a detection system using pickup coils made of cooled Cu Litz-wire and high-criticalerature superconductor (HTS) tape. The pickup coils were connected to a resonant capacitor in order to enhance the signal voltage generated in the pickup coils. The magnetic field noise at the resonant frequency of about 9 kHz was as low as 13 fT/Hz1/2 and 12 fT/Hz1/2 for the Cu and HTS coils, respectively. Next, we demonstrated the detection of nanoparticles using the cooled Cu coil and the third harmonic signal generated by the nonlinear magnetization of nanoparticles. An excitation field having a frequency of 3 kHz and root mean square value of 1.6 mT was applied to the magnetic particles, and the third harmonic signal at 9 kHz was detected that reduced the interference from the excitation field. We demonstrated the detection of 100 μg of magnetic nanoparticles. We obtained a clear contour map of the magnetic field from the particles, and could detect the particles located as far as 100 mm under the pickup coil.

Original languageEnglish
Article number6766251
JournalIEEE Transactions on Applied Superconductivity
Issue number4
Publication statusPublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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