TY - JOUR
T1 - Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus
T2 - Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures
AU - Isaka, Masahiko
AU - Chinthanom, Panida
AU - Choeyklin, Rattaket
AU - Thummarukcharoen, Tuksaporn
AU - Rachtawee, Pranee
AU - Sappan, Malipan
AU - Srichomthong, Kitlada
AU - Fujii, Ryoma
AU - Kawashima, Kyohei
AU - Mori, Seiji
N1 - Funding Information:
Financial support from the Thailand Research Fund (Grant No. DBG6280008) is gratefully acknowledged. Computational work at Ibaraki University was supported by Grants-in-Aid for Scientific Research (No. 18K05072 to S.M.) from JSPS and a Grant-in-Aid for Scientific Research on Innovative Areas “Precise Formation of a Catalyst Having a Specified Field for Use in Extremely Difficult Substrate Conversion Reactions” from MEXT, Japan (No. 18H04233 to S.M.). The generous allotment of computation time from the Research Center for Computational Science (RCCS), the National Institutes of Natural Sciences, Japan, is also gratefully acknowledged. We gratefully thank Prof. Stefan Grimme, Universität Bonn, for distributing to us an xTB program package. We thank Mr. W. Sanyapan for the permission for and technical support of the collection of the mushroom materials used in this study at his oil palm plantation. We are also grateful to Mr. B. Thaithatgoon, Arunyik Mushroom Center, for technology transfer of mushroom cultivation.
Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/7/24
Y1 - 2020/7/24
N2 - The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H (1-8) and ganodermalactones T-X (9-13), together with 23 known compounds (14-36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.
AB - The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H (1-8) and ganodermalactones T-X (9-13), together with 23 known compounds (14-36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.
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U2 - 10.1021/acs.jnatprod.9b00947
DO - 10.1021/acs.jnatprod.9b00947
M3 - Article
C2 - 32639735
AN - SCOPUS:85088607868
SN - 0163-3864
VL - 83
SP - 2066
EP - 2075
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -