Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Akio Ojida; Toru Yamano; Naohiro Taya; Akihiro Tasaka

doi:10.1021/ol0263189

Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Akio Ojida, Toru Yamano, Naohiro Taya, Akihiro Tasaka

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

(Matrix Presented) Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp²-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.

Original language	English
Pages (from-to)	3051-3054
Number of pages	4
Journal	Organic letters
Volume	4
Issue number	18
DOIs	https://doi.org/10.1021/ol0263189
Publication status	Published - Sept 5 2002

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0263189

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title = "Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination",

abstract = "(Matrix Presented) Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp2-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.",

author = "Akio Ojida and Toru Yamano and Naohiro Taya and Akihiro Tasaka",

year = "2002",

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T1 - Highly Enantioselective Reformatsky Reaction of Ketones

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AU - Yamano, Toru

AU - Taya, Naohiro

AU - Tasaka, Akihiro

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Y1 - 2002/9/5

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AB - (Matrix Presented) Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp2-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.

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Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Abstract

All Science Journal Classification (ASJC) codes

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