Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Shin Ya Furukawa; Gaku Hattori; Shinji Sakai; Noriho Kamiya

doi:10.1039/c6ra16926k

Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Shin Ya Furukawa, Gaku Hattori, Shinji Sakai, Noriho Kamiya

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.

Original language	English
Pages (from-to)	87753-87755
Number of pages	3
Journal	RSC Advances
Volume	6
Issue number	90
DOIs	https://doi.org/10.1039/c6ra16926k
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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abstract = "Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.",

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T1 - Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

AU - Furukawa, Shin Ya

AU - Hattori, Gaku

AU - Sakai, Shinji

AU - Kamiya, Noriho

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.

AB - Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.

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Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Abstract

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