Highly biodegradable bone substitute materials with OCP

Osamu Suzuki; Takahisa Anada

doi:10.1007/978-4-431-54070-0_96

Highly biodegradable bone substitute materials with OCP

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Biodegradation of the implanted bone substitute materials is an essential factor to determine the amount of newly formed bone. It is considered that one of ideal properties in the biomaterials is to have a biodegradation rate that coincides with the rate of new bone formation by osteoblasts. The purpose of the present article is to review on the biodegradation on one of calcium phosphate ceramics, octacalcium phosphate (OCP), and OCP-based polymer composites, such as OCP/alginate, we developed. OCP is more soluble than typical biodegradable β -tricalcium phosphate (β-TCP) ceramic but less soluble than dicalcium phosphate dihydrate (DCPD), a raw material used to form apatite cements. It has been shown that if OCP crystals are homogenously dispersed in the polymer matrices, then the composites enhance bone formation coupled with osteoclastic resorption of OCP crystals dispersed. The mechanism of the OCP biodegradation will be discussed.

Original language	English
Title of host publication	Interface Oral Health Science 2011
Publisher	Springer Japan
Pages	321-326
Number of pages	6
ISBN (Electronic)	9784431540700
ISBN (Print)	9784431540694
DOIs	https://doi.org/10.1007/978-4-431-54070-0_96
Publication status	Published - Jan 1 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dentistry(all)

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10.1007/978-4-431-54070-0_96

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AU - Anada, Takahisa

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N2 - Biodegradation of the implanted bone substitute materials is an essential factor to determine the amount of newly formed bone. It is considered that one of ideal properties in the biomaterials is to have a biodegradation rate that coincides with the rate of new bone formation by osteoblasts. The purpose of the present article is to review on the biodegradation on one of calcium phosphate ceramics, octacalcium phosphate (OCP), and OCP-based polymer composites, such as OCP/alginate, we developed. OCP is more soluble than typical biodegradable β -tricalcium phosphate (β-TCP) ceramic but less soluble than dicalcium phosphate dihydrate (DCPD), a raw material used to form apatite cements. It has been shown that if OCP crystals are homogenously dispersed in the polymer matrices, then the composites enhance bone formation coupled with osteoclastic resorption of OCP crystals dispersed. The mechanism of the OCP biodegradation will be discussed.

AB - Biodegradation of the implanted bone substitute materials is an essential factor to determine the amount of newly formed bone. It is considered that one of ideal properties in the biomaterials is to have a biodegradation rate that coincides with the rate of new bone formation by osteoblasts. The purpose of the present article is to review on the biodegradation on one of calcium phosphate ceramics, octacalcium phosphate (OCP), and OCP-based polymer composites, such as OCP/alginate, we developed. OCP is more soluble than typical biodegradable β -tricalcium phosphate (β-TCP) ceramic but less soluble than dicalcium phosphate dihydrate (DCPD), a raw material used to form apatite cements. It has been shown that if OCP crystals are homogenously dispersed in the polymer matrices, then the composites enhance bone formation coupled with osteoclastic resorption of OCP crystals dispersed. The mechanism of the OCP biodegradation will be discussed.

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Highly biodegradable bone substitute materials with OCP

Abstract

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