TY - GEN
T1 - High sensitive amperometric detection of glucose using conductive DLC electrode in higher potential region
AU - Honda, Kensuke
AU - Nakahara, Akira
AU - Naragino, Hiroshi
AU - Yoshinaga, Kohsuke
PY - 2013
Y1 - 2013
N2 - The possibility of a high sensitive amperometric detection of glucose using electrochemically-generated hydroxyl radicals at Ndoped DLC was examined. Flow injection analytical system using N-doped DLC as an electrode of electrochemical detector showed higher performance of glucose detection in a potential region of oxygen evolution (>3.6 V vs. Ag|AgCl). Linear dynamic range was 5 orders of magnitude (1 μM to 10 mM) and theoretical detection limit (S/N = 3) was 1.37 mM at 3.6 V vs. Ag|AgCl. In addition to glucose, linear relations between values of response current and of sample concentration were observed in molecules easily oxidized by OH radicals (ascorbic acid, 2-propanol, ethyl acetate and ethyl acetoacetate). The oxidation of glucose mediated by OH radicals generated at N-doped DLC in higher potential region is included in the mechanism of amperometric glucose detection at N-doped DLC.
AB - The possibility of a high sensitive amperometric detection of glucose using electrochemically-generated hydroxyl radicals at Ndoped DLC was examined. Flow injection analytical system using N-doped DLC as an electrode of electrochemical detector showed higher performance of glucose detection in a potential region of oxygen evolution (>3.6 V vs. Ag|AgCl). Linear dynamic range was 5 orders of magnitude (1 μM to 10 mM) and theoretical detection limit (S/N = 3) was 1.37 mM at 3.6 V vs. Ag|AgCl. In addition to glucose, linear relations between values of response current and of sample concentration were observed in molecules easily oxidized by OH radicals (ascorbic acid, 2-propanol, ethyl acetate and ethyl acetoacetate). The oxidation of glucose mediated by OH radicals generated at N-doped DLC in higher potential region is included in the mechanism of amperometric glucose detection at N-doped DLC.
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U2 - 10.1149/05012.0377ecst
DO - 10.1149/05012.0377ecst
M3 - Conference contribution
AN - SCOPUS:84885752659
SN - 9781607683605
T3 - ECS Transactions
SP - 377
EP - 383
BT - Chemical Sensors 10 -and- MEMS/NEMS 10
PB - Electrochemical Society Inc.
T2 - Symposia on Chemical Sensors 10 - Chemical and Biological Sensors and Analytical Systems and Microfabricated and Nanofabricated Systems for MEMS/NEMS 10 - 222nd ECS Meeting/PRiME 2012
Y2 - 7 October 2012 through 12 October 2012
ER -