High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease

Masashi Hamada, Yoshikazu Ugawa, Sadatoshi Tsuji, R. Kaji, S. Tobimatsu, K. Nakajima, Y. Nakamura, T. Fukudome, F. Yokochi, T. Komori, T. Chuma, M. Kitagawa, K. Matsunaga, S. Okabe, Y. Saito, N. Sugiyama, Y. Miyagi, T. Tanaka

    Research output: Contribution to journalArticlepeer-review

    126 Citations (Scopus)


    Dysfunction of the basal ganglia-thalamocortical motor circuit is a fundamental model to account for motor symptoms in Parkinson's disease (PD). Using high-frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA), we investigated whether modulation of SMA excitability engenders therapeutic effects on motor symptoms in PD. In this double-blind placebo-controlled study, 99 patients were enrolled and assigned randomly to SMA-stimulation and sham-stimulation groups. For SMA stimulation, 20 trains of 50 transcranial magnetic stimuli at 5 Hz were delivered at an intensity of 110% active motor threshold for leg muscles in one session. The sham stimulation was 20 trains of electric stimuli given through electrodes fixed on the head to mimic the cutaneous sensation during rTMS. Each session of intervention was carried out once a week for the first 8 weeks. The SMA stimulation, in contrast to the sham stimulation, engendered significant improvements in total scores and motor scores of the Unified Parkinson's Disease Rating Scale. Mean improvements in motor scores were 4.5 points in the SMA-stimulation group and -0.1 points in the sham-stimulation group. Results indicate that 5 Hz rTMS over SMA modestly improves motor symptoms in PD patients; SMA is a potential stimulation site for PD treatment.

    Original languageEnglish
    Pages (from-to)1524-1531
    Number of pages8
    JournalMovement Disorders
    Issue number11
    Publication statusPublished - Aug 15 2008

    All Science Journal Classification (ASJC) codes

    • Neurology
    • Clinical Neurology


    Dive into the research topics of 'High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease'. Together they form a unique fingerprint.

    Cite this