TY - JOUR
T1 - High-dose vitamin C therapy for inclusion body myositis.
AU - Yamada, T.
AU - Minohara, M.
AU - Imaiso, Y.
AU - Sakae, N.
AU - Hara, H.
AU - Tanaka, K.
AU - Yamamoto, T.
AU - Taniwaki, T.
AU - Furuya, H.
AU - Kira, J.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2001/4
Y1 - 2001/4
N2 - OBJECTIVES: The efficiency of high-dose vitamin C therapy for inclusion body myositis (IBM) was assessed. SUBJECTS & METHODS: The subjects were five patients with IBM confirmed pathologically. After the intravenous administration of 40 mg/kg vitamin C five times/week for four weeks, muscle weakness was found to improve in three cases. The average muscle score improved from 8.1 to 8.8, from 7.0 to 8.1 and from 6.2 to 6.8. Magnetic resonance imaging (MRI) demonstrated a reduction in the size of T2 high lesions and gadolinium enhancement in the thigh muscles in one case. Based on our findings, high-dose vitamin C therapy is considered to be effective in some cases of IBM.
AB - OBJECTIVES: The efficiency of high-dose vitamin C therapy for inclusion body myositis (IBM) was assessed. SUBJECTS & METHODS: The subjects were five patients with IBM confirmed pathologically. After the intravenous administration of 40 mg/kg vitamin C five times/week for four weeks, muscle weakness was found to improve in three cases. The average muscle score improved from 8.1 to 8.8, from 7.0 to 8.1 and from 6.2 to 6.8. Magnetic resonance imaging (MRI) demonstrated a reduction in the size of T2 high lesions and gadolinium enhancement in the thigh muscles in one case. Based on our findings, high-dose vitamin C therapy is considered to be effective in some cases of IBM.
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M3 - Article
C2 - 11411094
AN - SCOPUS:0035319048
SN - 0016-254X
VL - 92
SP - 99
EP - 104
JO - Fukuoka igaku zasshi = Hukuoka acta medica
JF - Fukuoka igaku zasshi = Hukuoka acta medica
IS - 4
ER -