TY - JOUR
T1 - Heteroatom-embedded medium-sized cycloalkynes
T2 - Concise synthesis, structural analysis, and reactions
AU - Ni, Runyan
AU - Mitsuda, Naoto
AU - Kashiwagi, Takeru
AU - Igawa, Kazunobu
AU - Tomooka, Katsuhiko
N1 - Publisher Copyright:
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA.
PY - 2015/1/19
Y1 - 2015/1/19
N2 - A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.
AB - A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.
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U2 - 10.1002/anie.201409910
DO - 10.1002/anie.201409910
M3 - Article
AN - SCOPUS:84920941113
SN - 1433-7851
VL - 54
SP - 1190
EP - 1194
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 4
ER -