TY - JOUR
T1 - Hemogenic endothelium
T2 - A vessel for blood production
AU - Antas, Veronica I.
AU - Al-Drees, Mohammad A.
AU - Prudence, Alexander J.A.
AU - Sugiyama, Daisuke
AU - Fraser, Stuart T.
N1 - Funding Information:
This review is a very condensed summary of a complex field and we apologise to the authors whose work we could not cite due to space restrictions. This work was supported by funding from the Sydney Medical School New Staff Grant and by the School of Medical Sciences, University of Sydney (STF). MAD is supported by the Department of Medical Oncology, Medical Oncology and Stem Cell Transplant Center, Ministry of Health, Kuwait . We thank the Research Support Center, Graduate School of Medical Sciences, Kyushu University and Miss Wai Feng Lim for technical support. We acknowledge Grant-in-Aids from the Ministry of Education, Culture, Sports, Science and Technology and Ministry of Health, Labor and Welfare (DS).
PY - 2013/3
Y1 - 2013/3
N2 - Blood cell production, or hematopoiesis, is critical to the survival of the developing mammalian embryo. The origins of hematopoietic stem cells, capable of giving rise to all blood cell types, are being revealed. During embryogenesis, hematopoietic stem and progenitor cells are generated from a unique population of vascular endothelium termed hemogenic endothelial cells. These unusual endothelial cells are found in a restricted number of sites in the conceptus and within a narrow window of embryonic development. Loss of hemogenic endothelial cells through gene ablation leads to a lack of blood production and embryonic lethality. Here, we describe historical and recent observations exploring the biology of these intriguing endothelial cells and their roles in hematopoiesis both in the embryo and, possibly, in the adult. Crown
AB - Blood cell production, or hematopoiesis, is critical to the survival of the developing mammalian embryo. The origins of hematopoietic stem cells, capable of giving rise to all blood cell types, are being revealed. During embryogenesis, hematopoietic stem and progenitor cells are generated from a unique population of vascular endothelium termed hemogenic endothelial cells. These unusual endothelial cells are found in a restricted number of sites in the conceptus and within a narrow window of embryonic development. Loss of hemogenic endothelial cells through gene ablation leads to a lack of blood production and embryonic lethality. Here, we describe historical and recent observations exploring the biology of these intriguing endothelial cells and their roles in hematopoiesis both in the embryo and, possibly, in the adult. Crown
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U2 - 10.1016/j.biocel.2012.12.013
DO - 10.1016/j.biocel.2012.12.013
M3 - Short survey
C2 - 23270729
AN - SCOPUS:84872582633
SN - 1357-2725
VL - 45
SP - 692
EP - 695
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 3
ER -