Hemodynamic factors associated with the development of hypertension

Motohiro Shimizu, Kazuomi Kario

Research output: Contribution to journalReview articlepeer-review


Recent studies have focused on the prevention of hypertension among high-risk, nonhypertensive individuals. In this review, we present that the deficiency of renal sodium excretion, small artery remodeling, and arterial stiffening might be potent mechanisms underlying the development of hypertension. The changes of these hemodynamic factors cause to increase blood pressure, and increasing blood pressure would accelerate those changes again. To break the vicious circle, not only the management of risk factors such as diabetes, obesity, or smoking, but also the intervention with antihypertensive agents is considered as a useful and effective procedure.

Original languageEnglish
Pages (from-to)1511-1516
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number8
Publication statusPublished - Aug 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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