Hemodynamic differences between the awake and anesthetized conditions in normal calves

Tohru Takaseya, Masako Fujiki, Akira Shiose, Hyun Il Kim, Mariko Kobayashi, Alex L. Massiello, Raymond Dessoffy, Sharif Al-Ruzzeh, Kiyotaka Fukamachi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


There is insufficient information in the literature about baseline circulatory parameters in normal calves in the anesthetized versus postoperative awake conditions under which a large volume of medical research is conducted. Eleven calves (mean body weight, 78.1 ± 14.3 kg) were implanted with a flow probe and fluid-filled pressure lines to measure cardiac output (CO), aortic (AoP), central venous (CVP), pulmonary arterial (PAP), and left atrial pressures (LAP). Systemic (SVR) and pulmonary vascular resistance (PVR) were also calculated. We obtained the above hemodynamic data (n = 11) and epicardial echocardiography (n = 7) during open-chest surgery under isoflurane anesthesia. After full recovery from surgery, animals were evaluated in the awake condition on postoperative days 6-9 using transthoracic echocardiography (n = 7) and the hemodynamic monitoring lines and probes noted (n = 11). CO, AoP, and PAP levels in the anesthetized condition were significantly lower than in the awake condition. Other hemodynamic parameters (CVP, LAP, SVR, and PVR) were not significantly different. In conclusion, data from this study quantify changes in CO, AoP, and PAP in anesthetized calves that may affect the hemodynamic response to experimental therapeutics such as new cardiac assist devices, prosthetic valves, and surgical interventions. Our study also provides baseline data for the translation of the hemodynamic data obtained in acute in vivo calf studies to that of an awake subject.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of Artificial Organs
Issue number3
Publication statusPublished - Sept 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Hemodynamic differences between the awake and anesthetized conditions in normal calves'. Together they form a unique fingerprint.

Cite this