TY - JOUR
T1 - Hemodynamic Characteristics After Fontan Procedure in Patients with Down’s Syndrome
AU - Otsuka, Masakazu
AU - Kodama, Yoshihiko
AU - Kuraoka, Ayako
AU - Ishikawa, Yuichi
AU - Nakamura, Makoto
AU - Nakano, Toshihide
AU - Kado, Hideaki
AU - Umemoto, Shintaro
AU - Ishikita, Ayako
AU - Sakamoto, Ichiro
AU - Ide, Tomomi
AU - Tsutsui, Hiroyuki
AU - Sagawa, Koichi
N1 - Funding Information:
We thank Jane Charbonneau, DVM, from Edanz Group (https://en-author-services.edanz.com/ac ) for editing a draft of this manuscript, and Junji Kishimoto, MA, from Center for Clinical and Translational Research, Kyushu University for advice on statistical analyses.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/2
Y1 - 2022/2
N2 - Patients with Down’s syndrome (DS) are generally regarded as not being good candidates for the Fontan procedure. However, detailed hemodynamic changes over time are not fully clarified. A retrospective chart review of all patients with DS who underwent the Fontan procedure and 5 times that number of Fontan patients without DS performed in Fukuoka Children’s Hospital and Kyushu University Hospital. Seven Fontan patients with DS were identified, and 35 Fontan patients without DS were recruited. During the mean observational periods of 14.7 years and 15.0 years (DS and non-DS, respectively) after the Fontan procedure, only one DS patient died. Central venous pressure (CVP) and transpulmonary pressure gradient significantly increased, and arterial oxygen saturation significantly decreased over time in DS patients after the Fontan procedure compared with those without DS. CVP in DS patients after the Fontan procedure increased over time compared with non-DS patients. Better management including the efficacy of Pulmonary arterial hypertension-specific therapy should be clarified in further studies.
AB - Patients with Down’s syndrome (DS) are generally regarded as not being good candidates for the Fontan procedure. However, detailed hemodynamic changes over time are not fully clarified. A retrospective chart review of all patients with DS who underwent the Fontan procedure and 5 times that number of Fontan patients without DS performed in Fukuoka Children’s Hospital and Kyushu University Hospital. Seven Fontan patients with DS were identified, and 35 Fontan patients without DS were recruited. During the mean observational periods of 14.7 years and 15.0 years (DS and non-DS, respectively) after the Fontan procedure, only one DS patient died. Central venous pressure (CVP) and transpulmonary pressure gradient significantly increased, and arterial oxygen saturation significantly decreased over time in DS patients after the Fontan procedure compared with those without DS. CVP in DS patients after the Fontan procedure increased over time compared with non-DS patients. Better management including the efficacy of Pulmonary arterial hypertension-specific therapy should be clarified in further studies.
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U2 - 10.1007/s00246-021-02727-6
DO - 10.1007/s00246-021-02727-6
M3 - Article
C2 - 34498105
AN - SCOPUS:85114395859
SN - 0172-0643
VL - 43
SP - 360
EP - 365
JO - Pediatric Cardiology
JF - Pediatric Cardiology
IS - 2
ER -