Hemodynamic and morphological changes in the dog kidney after injection of 5% ethanolamine oleate into the superior vena cava

The effect of the sclerosant 5% ethanolamine oleate (EO) on renal circulation was evaluated in 20 mongrel dogs into which we injected 5% EO (0.5 ml/kg) into the superior vena cava. There was a marked hemolysis and a significant decrease in creatinine clearance from 104.4 ± 17.1 (mean ± SD) to 40.7 ± 5.0 ml/min (p < 0.01) at 120 min. The renal arterial blood flow (RAF) decreased biphasically; from 75.3 ± 13.1 to 9.8 ± 9.3 ml/min during an average of 2.3 min, immediately after the injection (p < 0.01) and gradually decreased after reaching the pretreatment level to 43.2 ± 8.6 ml/min at 120 min (p < 0.01). Cardiac output significantly decreased from 1.86 ± 0.08 to 1.54 ± 0.08 1/min (p < 0.01). Tubular necrosis was histologically evidenced in the tissues examined at 6 h after the injection of EO. Biphasic decrease in renal arterial blood flow can be explained by the possible occurrence of spasm of the peripheral renal arteries in the acute phase and tubular necrosis in the late phase. This study suggests to us that the tubular necrosis induced by decreases in RAF as well as hemolytic nephropathy play a significant role in cases of renal dysfunction following the endoscopic injection of 5% EO to sclerose esophageal varices.