TY - JOUR
T1 - Helix pomatia agglutinin binding activity is a predictor of survival time for patients with gastric carcinoma
AU - Kakeji, Yoshihiro
AU - Tsujitani, Shunichi
AU - Mori, Masaki
AU - Maehara, Yoshihiko
AU - Sugimachi, Keizo
PY - 1991/12/1
Y1 - 1991/12/1
N2 - The authors used helix pomatia agglutinin (HPA) staining to examine 163 primary gastric carcinoma isolates, using the avidin‐biotin‐peroxidase complex method. The positive HPA staining rate was 59% (96/163) for the primary tumors, and the positive staining correlated well (with statistical significance) with tumor enlargement, penetration, lymphatic invasion, and metastasis (P < 0.01), and with infiltrative spread (P < 0.05). Patients with gastric cancer showing positive HPA staining had a lower survival rate (P < 0.001), particularly when the cancer cells were present on the serosal surface. Careful follow‐up and intensive postoperative therapy are required for patients with an HPA‐positive advanced gastric carcinoma. 68:2438‐2442, 1991.
AB - The authors used helix pomatia agglutinin (HPA) staining to examine 163 primary gastric carcinoma isolates, using the avidin‐biotin‐peroxidase complex method. The positive HPA staining rate was 59% (96/163) for the primary tumors, and the positive staining correlated well (with statistical significance) with tumor enlargement, penetration, lymphatic invasion, and metastasis (P < 0.01), and with infiltrative spread (P < 0.05). Patients with gastric cancer showing positive HPA staining had a lower survival rate (P < 0.001), particularly when the cancer cells were present on the serosal surface. Careful follow‐up and intensive postoperative therapy are required for patients with an HPA‐positive advanced gastric carcinoma. 68:2438‐2442, 1991.
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U2 - 10.1002/1097-0142(19911201)68:11<2438::AID-CNCR2820681119>3.0.CO;2-#
DO - 10.1002/1097-0142(19911201)68:11<2438::AID-CNCR2820681119>3.0.CO;2-#
M3 - Article
C2 - 1718583
AN - SCOPUS:0026337287
SN - 0008-543X
VL - 68
SP - 2438
EP - 2442
JO - Cancer
JF - Cancer
IS - 11
ER -
