TY - JOUR
T1 - GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits
AU - Matoba, Nana
AU - Akiyama, Masato
AU - Ishigaki, Kazuyoshi
AU - Kanai, Masahiro
AU - Takahashi, Atsushi
AU - Momozawa, Yukihide
AU - Ikegawa, Shiro
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Hirata, Makoto
AU - Matsuda, Koichi
AU - Murakami, Yoshinori
AU - Kubo, Michiaki
AU - Kamatani, Yoichiro
AU - Okada, Yukinori
N1 - Funding Information:
We are grateful to all participants enrolled in BBJ. We thank all the clinicians and organizations that contributed to the collection of samples and clinical information. This research was supported by the Tailor-Made Medical Treatment Programme (BBJ) of the Ministry of Education, Culture, Sports, Science and Technology and the Japan Agency for Medical Research and Development (AMED; grant nos. JP17km0305002, JP19km0405201 and JP19km045208), and by the Strategic Research Programme for Brain Sciences of AMED (no. JP19dm0107097). Y.O. was supported by the Japan Society for the Promotion of Science, KAKENHI (nos. 15H05911 and 19H01021), AMED (nos. JP19gm6010001, JP19ek0410041, JP19ek0109413 and JP19km0405211), Takeda Science Foundation and the Bioinformatics Initiative of Osaka University Graduate School of Medicine, Osaka University and Osaka University Centre of Medical Data Science, Advanced Clinical Epidemiology Investigator’s Research Project. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610–165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P < 3.8 × 10−9). Of these, ten associations between five loci and eight traits were new findings. Furthermore, a phenome-wide association study revealed that five of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases and clinical measurements. Our findings provide new insight into the genetics of habitual consumption.
AB - Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610–165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P < 3.8 × 10−9). Of these, ten associations between five loci and eight traits were new findings. Furthermore, a phenome-wide association study revealed that five of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases and clinical measurements. Our findings provide new insight into the genetics of habitual consumption.
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U2 - 10.1038/s41562-019-0805-1
DO - 10.1038/s41562-019-0805-1
M3 - Article
C2 - 31959922
AN - SCOPUS:85078282025
SN - 2397-3374
VL - 4
SP - 308
EP - 316
JO - Nature human behaviour
JF - Nature human behaviour
IS - 3
ER -
