Growth and apoptosis of human natural killer cell neoplasms: Role of interleukin-2/15 signaling

Satoshi Yamasaki; Motoi Maeda; Koichi Ohshima; Masahiro Kikuchi; Teruhisa Otsuka; Mine Harada

doi:10.1016/j.leukres.2004.02.006

Growth and apoptosis of human natural killer cell neoplasms: Role of interleukin-2/15 signaling

Satoshi Yamasaki, Motoi Maeda, Koichi Ohshima, Masahiro Kikuchi, Teruhisa Otsuka, Mine Harada

Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X _L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.

Original language	English
Pages (from-to)	1023-1031
Number of pages	9
Journal	Leukemia Research
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.leukres.2004.02.006
Publication status	Published - Oct 2004

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.leukres.2004.02.006

Cite this

@article{a8321588177343fc8fc090767d3ce339,

title = "Growth and apoptosis of human natural killer cell neoplasms: Role of interleukin-2/15 signaling",

abstract = "Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.",

author = "Satoshi Yamasaki and Motoi Maeda and Koichi Ohshima and Masahiro Kikuchi and Teruhisa Otsuka and Mine Harada",

year = "2004",

month = oct,

doi = "10.1016/j.leukres.2004.02.006",

language = "English",

volume = "28",

pages = "1023--1031",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "10",

}

TY - JOUR

T1 - Growth and apoptosis of human natural killer cell neoplasms

T2 - Role of interleukin-2/15 signaling

AU - Yamasaki, Satoshi

AU - Maeda, Motoi

AU - Ohshima, Koichi

AU - Kikuchi, Masahiro

AU - Otsuka, Teruhisa

AU - Harada, Mine

PY - 2004/10

Y1 - 2004/10

N2 - Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.

AB - Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.

UR - http://www.scopus.com/inward/record.url?scp=3843099310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3843099310&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2004.02.006

DO - 10.1016/j.leukres.2004.02.006

M3 - Article

C2 - 15289013

AN - SCOPUS:3843099310

SN - 0145-2126

VL - 28

SP - 1023

EP - 1031

JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

Growth and apoptosis of human natural killer cell neoplasms: Role of interleukin-2/15 signaling

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this