Green tea cultivar ‘Benifuuki’ potentiates split vaccine-induced immunoglobulin A production

Yeong Seon Won, Motofumi Kumazoe, Kanako Takamatsu, Yuki Shinoda, Saki Sonoda, Kenji Okada, Takehisa Okamoto, Hirofumi Tachibana

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Influenza is a widespread disease caused by infection with the influenza virus. Vaccination is considered to be the main countermeasure against influenza. A split vaccine is widely used to avoid severe adverse events, and it induces strong humoral immunity. However, the split vaccine alone cannot elicit mucosal immunity, including IgA production, and its preventative effects are limited. Here, we show that the green tea cultivar ‘Benifuuki’ extract enhanced the effect of a split vaccine on mucosal immunity. The frequency of IgA+ cells was increased in lung and Peyer’s patch that received Benifuuki diet. Secretion of hemagglutinin-specific mucosal IgA, which is closely linked to the prevention of viral infection, was significantly increased in the bronchoalveolar lavage fluid of split vaccine-immunized BALB/c mice that were administered green tea Benifuuki extract. Our findings suggest that Benifuuki intake enhanced the effects of the split vaccine on mucosal immunity.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Natural Medicines
Issue number1
Publication statusPublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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