Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 ​μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

Original languageEnglish
Article number100247
JournalMaterials Today Bio
Volume14
DOIs
Publication statusPublished - Mar 2022

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

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