TY - JOUR
T1 - GNRA/receptor interacting modules
T2 - Versatile modular units for natural and artificial RNA architectures
AU - Ishikawa, Junya
AU - Fujita, Yuki
AU - Maeda, Yuri
AU - Furuta, Hiroyuki
AU - Ikawa, Yoshiya
N1 - Funding Information:
Our work is supported by PRESTO, Japan Science and Technology Agency (JST), Japan and also by Grants-in-Aids on Innovative Areas “Emergence in Chemistry” (No. 21111518 to Y.I.) and for the Global COE Program “Science for Future Molecular Systems” (H.F.) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan. We also thank the anonymous reviewers for their helpful comments.
PY - 2011/6
Y1 - 2011/6
N2 - Interactions between GNRA tetraloops and their receptors are found frequently as modular units in various types of naturally occurring structured RNAs. Due to their functional importance, GNRA/receptor interactions have been studied extensively with regard to their 3D structures and biochemical and biophysical properties. Artificial non-natural GNRA/receptor modules have also been generated not only to obtain a better understanding of this class of motifs in natural RNA structures but also for application of these modular units to the design and construction of artificial RNA structures that can be used as platforms to generate functional RNAs applicable for nanobiotechnology. In this review, we present a survey of structures, functions, and analyses as well as artificial generation and application of GNRA/receptor interacting modules.
AB - Interactions between GNRA tetraloops and their receptors are found frequently as modular units in various types of naturally occurring structured RNAs. Due to their functional importance, GNRA/receptor interactions have been studied extensively with regard to their 3D structures and biochemical and biophysical properties. Artificial non-natural GNRA/receptor modules have also been generated not only to obtain a better understanding of this class of motifs in natural RNA structures but also for application of these modular units to the design and construction of artificial RNA structures that can be used as platforms to generate functional RNAs applicable for nanobiotechnology. In this review, we present a survey of structures, functions, and analyses as well as artificial generation and application of GNRA/receptor interacting modules.
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U2 - 10.1016/j.ymeth.2010.12.011
DO - 10.1016/j.ymeth.2010.12.011
M3 - Review article
C2 - 21163353
AN - SCOPUS:79958698086
SN - 1046-2023
VL - 54
SP - 226
EP - 238
JO - Methods
JF - Methods
IS - 2
ER -