GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Kenjiro Date; Takao Ohtsuka; Takaaki Fujimoto; Yoshitaka Gotoh; Yohei Nakashima; Hideyo Kimura; Taketo Matsunaga; Yasuhisa Mori; Naoki Mochidome; Tetsuyuki Miyazaki; Yoshinao Oda; Masao Tanaka; Masafumi Nakamura

doi:10.1016/j.pan.2015.09.013

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Kenjiro Date, Takao Ohtsuka, Takaaki Fujimoto, Yoshitaka Gotoh, Yohei Nakashima, Hideyo Kimura, Taketo Matsunaga, Yasuhisa Mori, Naoki Mochidome, Tetsuyuki Miyazaki, Yoshinao Oda, Masao Tanaka, Masafumi Nakamura

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	Pancreatology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.pan.2015.09.013
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pan.2015.09.013

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Date, K., Ohtsuka, T., Fujimoto, T., Gotoh, Y., Nakashima, Y., Kimura, H., Matsunaga, T., Mori, Y., Mochidome, N., Miyazaki, T., Oda, Y., Tanaka, M., & Nakamura, M. (2015). GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report. Pancreatology, 15(6), 713-716. https://doi.org/10.1016/j.pan.2015.09.013

Date, K, Ohtsuka, T, Fujimoto, T, Gotoh, Y, Nakashima, Y, Kimura, H, Matsunaga, T, Mori, Y, Mochidome, N, Miyazaki, T, Oda, Y, Tanaka, M & Nakamura, M 2015, 'GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report', Pancreatology, vol. 15, no. 6, pp. 713-716. https://doi.org/10.1016/j.pan.2015.09.013

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title = "GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report",

abstract = "Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.",

author = "Kenjiro Date and Takao Ohtsuka and Takaaki Fujimoto and Yoshitaka Gotoh and Yohei Nakashima and Hideyo Kimura and Taketo Matsunaga and Yasuhisa Mori and Naoki Mochidome and Tetsuyuki Miyazaki and Yoshinao Oda and Masao Tanaka and Masafumi Nakamura",

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AU - Ohtsuka, Takao

AU - Fujimoto, Takaaki

AU - Gotoh, Yoshitaka

AU - Nakashima, Yohei

AU - Kimura, Hideyo

AU - Matsunaga, Taketo

AU - Mori, Yasuhisa

AU - Mochidome, Naoki

AU - Miyazaki, Tetsuyuki

AU - Oda, Yoshinao

AU - Tanaka, Masao

AU - Nakamura, Masafumi

PY - 2015

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AB - Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

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GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Abstract

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