Glycolipids Regulate Ameloblast Differentiation

Satoshi Fukumoto, Aya Yamada, Emiko Fukumoto, Kenji Yuasa, Keigo Yoshizaki, Tsutomu Iwamoto, Kazuaki Nonaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Tooth development is regulated by sequential and reciprocal interaction between the oral ectoderm and mesenchyme. Glycolipids regulate the signaling of growth factor receptor and cell adhesion to extracellular matrix; however, the role of glycolipids in ameloblast differentiation is scarcely understood. GD3 synthase is a glycolipid synthase. The GD3 synthase gene was highly expressed during the embryonic stage of dental epithelium, but not in dental mesenchyme. Dental epithelium transiently transfected with the GD3 synthase gene was shown to enhance its proliferation and inhibit enamel matrix expression. These results may indicate regulatory roles of glycolipids in cell proliferation and the differentiation of ameloblasts.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
Journaljournal of oral biosciences
Issue number2
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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