Glycoglycan Mimic by Synthetic Polymers

Yoshiko Miura, Tomohiro Fukuda, Yu Hoshino

Research output: Chapter in Book/Report/Conference proceedingChapter


Glycosaminoglycans (GAGs) are important polysaccharides in the living system, but the availability of GAGs is limited due to the complicated structures. In this investigation, GAGs were re-organized by synthetic glycopolymers. GAGs mimic glycopolymers were synthesized by polymerization of acrylamide sugar derivatives carrying sulfated N-acetyl glucosamine (GlcNAc). The interaction with proteins were investigated in view of inhibition of Alzheimer disease. The glycopolymer were prepared as molecular library with changing molecular weight, sugar structure and sugar ratios. The inhibitory activity of Alzheimer disease was studied by inhibitions of protein amyloidosis of amyloid beta (Aβ) peptides. The biological activities depended on the chemical structure of glycopolymers. We found the correlation of glycopolymer activities to the native GAGs.

Original languageEnglish
Title of host publicationACS Symposium Series
EditorsYoshihiro Ito, Xuesi Chen, Inn-Kyu Kang
PublisherAmerican Chemical Society
Number of pages9
Publication statusPublished - 2017

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)


Dive into the research topics of 'Glycoglycan Mimic by Synthetic Polymers'. Together they form a unique fingerprint.

Cite this