TY - JOUR
T1 - Glycated albumin as a diagnostic tool for diabetes in a general Japanese population
AU - Ikezaki, Hiroaki
AU - Furusyo, Norihiro
AU - Ihara, Takeshi
AU - Hayashi, Takeo
AU - Ura, Kazuya
AU - Hiramine, Satoshi
AU - Mitsumoto, Fujiko
AU - Takayama, Koji
AU - Murata, Masayuki
AU - Kohzuma, Takuji
AU - Ai, Masumi
AU - Schaefer, Ernst J.
AU - Hayashi, Jun
N1 - Funding Information:
This work was supported by the Japan Heart Foundation/Bayer Yakuhin Research Grant Abroad, the Japan Multi-institutional Collaborative Cohort Study (J-MICC Study), a Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas (grant number 221S001), and a Grant-in-Aid for Comprehensive Research of the 21st Century COE Program from the Ministry of Education, Culture, Sports Science and Technology of Japan.
Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5% received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.
AB - Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5% received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=84927970888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927970888&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2015.03.003
DO - 10.1016/j.metabol.2015.03.003
M3 - Article
C2 - 25817605
AN - SCOPUS:84927970888
SN - 0026-0495
VL - 64
SP - 698
EP - 705
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 6
ER -
