Ghrelin strongly stimulates growth hormone (GH) release in humans

Kazuhiko Takaya, Hiroyuki Ariyasu, Naotetsu Kanamoto, Hiroshi Iwakura, Akihiro Yoshimoto, Masaki Harada, Kiyoshi Mori, Yasato Komatsu, Takeshi Usui, Akira Shimatsu, Yoshihiro Ogawa, Kiminori Hosoda, Takashi Akamizu, Masayasu Kojima, Kenji Kangawa, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

801 Citations (Scopus)


Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 μg/kg ghrelin produced 43.3 ± 6.0, 81.5 ± 12.7, and 107.0 ± 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 μg/kg) resulted in only minimum peak values of these hormones (22.8 ± 3.0 pg/mL, 9.4 ± 1.9 μg/dL, and 4.6 ± 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans.

Original languageEnglish
Pages (from-to)4908-4911
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number12
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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