TY - JOUR
T1 - GFRα3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion
AU - Nishino, Jinsuke
AU - Mochida, Kyoko
AU - Ohfuji, Yasuhisa
AU - Shimazaki, Takuya
AU - Meno, Chikara
AU - Ohishi, Sachiko
AU - Matsuda, Yoichi
AU - Fujii, Hideta
AU - Saijoh, Yukio
AU - Hamada, Hiroshi
N1 - Funding Information:
We thank Hisato Kondoh for introducing us to ES cell–mediated gene targeting, Shintaro Nomura for his advice on in situ hybridization, Tomoyuki Ichikawa for an anti-ChAT antibody, and Kazuto Kobayashi for TH and DBH probes. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan and by CREST.
PY - 1999/8
Y1 - 1999/8
N2 - GFRα3 is a component of the receptor for the neurotrophic factor artemin. The role of GFRα3 in nervous system development was examined by generating mice in which the Gfrα3 gene was disrupted. The Gfrα3-/-) mice exhibited severe defects in the superior cervical ganglion (SCG), whereas other ganglia appeared normal. SCG precursor cells in the mutant embryos failed to migrate to the correct position, and they subsequently failed to innervate the target organs. In wild-type embryos, Gfrα3 was expressed in migrating SCG precursors, and artemin was expressed in and near the SCG. After birth, SCG neurons in the mutant mice underwent progressive cell death. These observations suggest that GFRα3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons.
AB - GFRα3 is a component of the receptor for the neurotrophic factor artemin. The role of GFRα3 in nervous system development was examined by generating mice in which the Gfrα3 gene was disrupted. The Gfrα3-/-) mice exhibited severe defects in the superior cervical ganglion (SCG), whereas other ganglia appeared normal. SCG precursor cells in the mutant embryos failed to migrate to the correct position, and they subsequently failed to innervate the target organs. In wild-type embryos, Gfrα3 was expressed in migrating SCG precursors, and artemin was expressed in and near the SCG. After birth, SCG neurons in the mutant mice underwent progressive cell death. These observations suggest that GFRα3-mediated signaling is required both for the rostral migration of SCG precursors and for the survival of mature SCG neurons.
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U2 - 10.1016/S0896-6273(01)80031-3
DO - 10.1016/S0896-6273(01)80031-3
M3 - Article
C2 - 10482239
AN - SCOPUS:0033172962
SN - 0896-6273
VL - 23
SP - 725
EP - 736
JO - Neuron
JF - Neuron
IS - 4
ER -