Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

Hajime Nawata; Senji Shirasawa; Naoki Nakashima; Eiichi Araki; Jun Hashiguchi; Seibei Miyake; Teruaki Yamauchi; Kazuyuki Hamaguchi; Hironobu Yoshimatsu; Haruo Takeda; Hideo Fukushima; Takayuki Sasahara; Kohei Yamaguchi; Noriyuki Sonoda; Tomoko Sonoda; Masahiro Matsumoto; Yoshiya Tanaka; Hidekatsu Sugimoto; Hirotaka Tsubouchi; Toyoshi Inoguchi; Toshihiko Yanase; Nakayasu Wake; Kenziro Narazaki; Takashi Eto; Fumio Umeda; Mitsuhiro Nakazaki; Junko Ono; Takashi Asano; Yasuko Ito; Shoichi Akazawa; Iwaho Hazegawa; Nobuyuki Takasu; Moritsugu Shinohara; Takeshi Nishikawa; Seiho Nagafuchi; Toshimitsu Okeda; Katsumi Eguchi; Masanori Iwase; Mayuko Ishikawa; Masayuki Aoki; Naoto Keicho; Norihiro Kato; Kazuki Yasuda; Ken Yamamoto; Takehiko Sasazuki

doi:10.1007/s10038-004-0199-3

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

Hajime Nawata, Senji Shirasawa, Naoki Nakashima, Eiichi Araki, Jun Hashiguchi, Seibei Miyake, Teruaki Yamauchi, Kazuyuki Hamaguchi, Hironobu Yoshimatsu, Haruo Takeda, Hideo Fukushima, Takayuki Sasahara, Kohei Yamaguchi, Noriyuki Sonoda, Tomoko Sonoda, Masahiro Matsumoto, Yoshiya Tanaka, Hidekatsu Sugimoto, Hirotaka Tsubouchi, Toyoshi InoguchiToshihiko Yanase, Nakayasu Wake, Kenziro Narazaki, Takashi Eto, Fumio Umeda, Mitsuhiro Nakazaki, Junko Ono, Takashi Asano, Yasuko Ito, Shoichi Akazawa, Iwaho Hazegawa, Nobuyuki Takasu, Moritsugu Shinohara, Takeshi Nishikawa, Seiho Nagafuchi, Toshimitsu Okeda, Katsumi Eguchi, Masanori Iwase, Mayuko Ishikawa, Masayuki Aoki, Naoto Keicho, Norihiro Kato, Kazuki Yasuda, Ken Yamamoto, Takehiko Sasazuki

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Abstract

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [ D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

Original language	English
Pages (from-to)	629-634
Number of pages	6
Journal	Journal of Human Genetics
Volume	49
Issue number	11
DOIs	https://doi.org/10.1007/s10038-004-0199-3
Publication status	Published - Nov 2004

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Genetics
Genetics(clinical)

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Nawata, H., Shirasawa, S., Nakashima, N., Araki, E., Hashiguchi, J., Miyake, S., Yamauchi, T., Hamaguchi, K., Yoshimatsu, H., Takeda, H., Fukushima, H., Sasahara, T., Yamaguchi, K., Sonoda, N., Sonoda, T., Matsumoto, M., Tanaka, Y., Sugimoto, H., Tsubouchi, H., ... Sasazuki, T. (2004). Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese. Journal of Human Genetics, 49(11), 629-634. https://doi.org/10.1007/s10038-004-0199-3

Nawata, H, Shirasawa, S, Nakashima, N, Araki, E, Hashiguchi, J, Miyake, S, Yamauchi, T, Hamaguchi, K, Yoshimatsu, H, Takeda, H, Fukushima, H, Sasahara, T, Yamaguchi, K, Sonoda, N, Sonoda, T, Matsumoto, M, Tanaka, Y, Sugimoto, H, Tsubouchi, H, Inoguchi, T, Yanase, T, Wake, N, Narazaki, K, Eto, T, Umeda, F, Nakazaki, M, Ono, J, Asano, T, Ito, Y, Akazawa, S, Hazegawa, I, Takasu, N, Shinohara, M, Nishikawa, T, Nagafuchi, S, Okeda, T, Eguchi, K, Iwase, M, Ishikawa, M, Aoki, M, Keicho, N, Kato, N, Yasuda, K, Yamamoto, K & Sasazuki, T 2004, 'Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese', Journal of Human Genetics, vol. 49, no. 11, pp. 629-634. https://doi.org/10.1007/s10038-004-0199-3

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title = "Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese",

abstract = "Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [ D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.",

author = "Hajime Nawata and Senji Shirasawa and Naoki Nakashima and Eiichi Araki and Jun Hashiguchi and Seibei Miyake and Teruaki Yamauchi and Kazuyuki Hamaguchi and Hironobu Yoshimatsu and Haruo Takeda and Hideo Fukushima and Takayuki Sasahara and Kohei Yamaguchi and Noriyuki Sonoda and Tomoko Sonoda and Masahiro Matsumoto and Yoshiya Tanaka and Hidekatsu Sugimoto and Hirotaka Tsubouchi and Toyoshi Inoguchi and Toshihiko Yanase and Nakayasu Wake and Kenziro Narazaki and Takashi Eto and Fumio Umeda and Mitsuhiro Nakazaki and Junko Ono and Takashi Asano and Yasuko Ito and Shoichi Akazawa and Iwaho Hazegawa and Nobuyuki Takasu and Moritsugu Shinohara and Takeshi Nishikawa and Seiho Nagafuchi and Toshimitsu Okeda and Katsumi Eguchi and Masanori Iwase and Mayuko Ishikawa and Masayuki Aoki and Naoto Keicho and Norihiro Kato and Kazuki Yasuda and Ken Yamamoto and Takehiko Sasazuki",

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doi = "10.1007/s10038-004-0199-3",

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T1 - Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

AU - Nawata, Hajime

AU - Shirasawa, Senji

AU - Nakashima, Naoki

AU - Araki, Eiichi

AU - Hashiguchi, Jun

AU - Miyake, Seibei

AU - Yamauchi, Teruaki

AU - Hamaguchi, Kazuyuki

AU - Yoshimatsu, Hironobu

AU - Takeda, Haruo

AU - Fukushima, Hideo

AU - Sasahara, Takayuki

AU - Yamaguchi, Kohei

AU - Sonoda, Noriyuki

AU - Sonoda, Tomoko

AU - Matsumoto, Masahiro

AU - Tanaka, Yoshiya

AU - Sugimoto, Hidekatsu

AU - Tsubouchi, Hirotaka

AU - Inoguchi, Toyoshi

AU - Yanase, Toshihiko

AU - Wake, Nakayasu

AU - Narazaki, Kenziro

AU - Eto, Takashi

AU - Umeda, Fumio

AU - Nakazaki, Mitsuhiro

AU - Ono, Junko

AU - Asano, Takashi

AU - Ito, Yasuko

AU - Akazawa, Shoichi

AU - Hazegawa, Iwaho

AU - Takasu, Nobuyuki

AU - Shinohara, Moritsugu

AU - Nishikawa, Takeshi

AU - Nagafuchi, Seiho

AU - Okeda, Toshimitsu

AU - Eguchi, Katsumi

AU - Iwase, Masanori

AU - Ishikawa, Mayuko

AU - Aoki, Masayuki

AU - Keicho, Naoto

AU - Kato, Norihiro

AU - Yasuda, Kazuki

AU - Yamamoto, Ken

AU - Sasazuki, Takehiko

PY - 2004/11

Y1 - 2004/11

N2 - Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [ D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

AB - Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [ D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

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Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese

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