Genetics of supernumerary tooth formation

Takashi Nakamura, Satoshi Fukumoto

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Tooth development is initiated with placode formation followed by thickening of the oral ectoderm-derived dental epithelium. The dental epithelium then undergoes invagination into the dental mesench-yme, which is derived from the cranial neural crest. The subsequent reciprocal interactions between the dental epithelium and mesenchyme, involving a variety of molecules, are important for tooth morphogenesis, as well as for regulation of tooth number. Recent analyses of mouse mutants have provided important insights into the mechanisms underlying tooth development, including supernumerary tooth formation. In this review, we have discussed the molecular basis for the regulation of tooth number and supernumerary tooth formation.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
Journaljournal of oral biosciences
Issue number4
Publication statusPublished - Nov 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dentistry(all)


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