Genetics of Circadian Rhythms

Tomas S Andreani, Taichi Q Itoh, Evrim Yildirim, Dae-Sung Hwangbo, Ravi Allada

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)


Nearly all organisms exhibit time-dependent behavior and physiology across a 24-hour day known as circadian rhythms. These outputs are manifestations of endogenous cyclic gene expression patterns driven by the activity of a core transcription/translation feedback loop. Cyclic gene expression determines highly tissue-specific functional activity regulating such processes as metabolic state, endocrine activity, and neural excitability. Entrainment of these cellular clocks is achieved through exogenous daily inputs, such as light and food. Dysregulation of the transcription/translation feedback loop has been shown to result in a wide range of disorders and diseases driving increased interest in circadian therapies.

Original languageEnglish
Pages (from-to)413-21
Number of pages9
JournalSleep Medicine Clinics
Issue number4
Publication statusPublished - Dec 2015


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