TY - JOUR
T1 - Genetic structure of the dopamine receptor D4 gene (DRD4) and lack of association with schizophrenia in Japanese patients
AU - Mitsuyasu, Hiroshi
AU - Kawasaki, Hiroaki
AU - Ninomiya, Hideaki
AU - Kinukawa, Naoko
AU - Yamanaka, Takeharu
AU - Tahira, Tomoko
AU - Stanton, Vincent P.
AU - Springett, Gregory M.
AU - Hayashi, Kenshi
AU - Tashiro, Nobutada
AU - Kanba, Shigenobu
PY - 2007/11
Y1 - 2007/11
N2 - In order to investigate the contribution of genetic variation in the human dopamine receptor D4 gene (DRD4) to the risk of developing schizophrenia, we carried out a genetic analysis of 27 polymorphisms in 216 schizophrenic patients and 243 healthy controls from the Kyushu region of Japan. Twenty-two single nucleotide polymorphisms (SNPs) and five insertion/deletion polymorphisms were analyzed in this study, including four novel SNPs and a novel mononucleotide repeat. Linkage disequilibrium (LD) and haplotype analyses reveal weak LD across the DRD4 gene. In univariate analysis female individuals with allele -521C had a higher risk for schizophrenia. However, this finding was not significant after correction for multiple hypothesis testing. No other polymorphisms or haplotypes differed between schizophrenic patients and controls. Likewise, multivariate analyses did not reveal any statistically significant associations.
AB - In order to investigate the contribution of genetic variation in the human dopamine receptor D4 gene (DRD4) to the risk of developing schizophrenia, we carried out a genetic analysis of 27 polymorphisms in 216 schizophrenic patients and 243 healthy controls from the Kyushu region of Japan. Twenty-two single nucleotide polymorphisms (SNPs) and five insertion/deletion polymorphisms were analyzed in this study, including four novel SNPs and a novel mononucleotide repeat. Linkage disequilibrium (LD) and haplotype analyses reveal weak LD across the DRD4 gene. In univariate analysis female individuals with allele -521C had a higher risk for schizophrenia. However, this finding was not significant after correction for multiple hypothesis testing. No other polymorphisms or haplotypes differed between schizophrenic patients and controls. Likewise, multivariate analyses did not reveal any statistically significant associations.
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U2 - 10.1016/j.jpsychires.2006.05.014
DO - 10.1016/j.jpsychires.2006.05.014
M3 - Article
C2 - 16887146
AN - SCOPUS:34247513982
SN - 0022-3956
VL - 41
SP - 763
EP - 775
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 9
ER -
