Genetic mutual relationship between PTEN and p53 in gastric cancer

Eiji Oki; Eriko Tokunaga; Toshihiko Nakamura; Naoyuki Ueda; Motonori Futatsugi; Kohjiro Mashino; Manabu Yamamoto; Masayuki Watanabe; Masahiko Ikebe; Yoshihiro Kakeji; Hideo Baba; Yoshihiko Maehara

doi:10.1016/j.canlet.2004.12.006

Genetic mutual relationship between PTEN and p53 in gastric cancer

Eiji Oki, Eriko Tokunaga, Toshihiko Nakamura, Naoyuki Ueda, Motonori Futatsugi, Kohjiro Mashino, Manabu Yamamoto, Masayuki Watanabe, Masahiko Ikebe, Yoshihiro Kakeji, Hideo Baba, Yoshihiko Maehara

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Abstract

Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	Cancer Letters
Volume	227
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.12.006
Publication status	Published - Sept 8 2005

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2004.12.006

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title = "Genetic mutual relationship between PTEN and p53 in gastric cancer",

abstract = "Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.",

author = "Eiji Oki and Eriko Tokunaga and Toshihiko Nakamura and Naoyuki Ueda and Motonori Futatsugi and Kohjiro Mashino and Manabu Yamamoto and Masayuki Watanabe and Masahiko Ikebe and Yoshihiro Kakeji and Hideo Baba and Yoshihiko Maehara",

note = "Funding Information: We are grateful to J. Tsuchihashi, K. Miyamoto, N. Nakamura, Y. Kubota, Y. Matsumoto and T. Shishino for technical assistance. This study was supported by grants from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2005",

month = sep,

day = "8",

doi = "10.1016/j.canlet.2004.12.006",

language = "English",

volume = "227",

pages = "33--38",

journal = "Cancer Letters",

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TY - JOUR

T1 - Genetic mutual relationship between PTEN and p53 in gastric cancer

AU - Oki, Eiji

AU - Tokunaga, Eriko

AU - Nakamura, Toshihiko

AU - Ueda, Naoyuki

AU - Futatsugi, Motonori

AU - Mashino, Kohjiro

AU - Yamamoto, Manabu

AU - Watanabe, Masayuki

AU - Ikebe, Masahiko

AU - Kakeji, Yoshihiro

AU - Baba, Hideo

AU - Maehara, Yoshihiko

N1 - Funding Information: We are grateful to J. Tsuchihashi, K. Miyamoto, N. Nakamura, Y. Kubota, Y. Matsumoto and T. Shishino for technical assistance. This study was supported by grants from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2005/9/8

Y1 - 2005/9/8

N2 - Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.

AB - Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.

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DO - 10.1016/j.canlet.2004.12.006

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AN - SCOPUS:22744452500

SN - 0304-3835

VL - 227

SP - 33

EP - 38

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Genetic mutual relationship between PTEN and p53 in gastric cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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