Genetic diversity of enterohemorrhagic Escherichia coli

Makoto Ohnishi, Tetsuya Hayashi

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Enterohemorrhagic Escherichia coli(EHEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Genomic comparison of an EHEC O157: H7 strain isolated from the Sakai outbreak and a benign laboratory strain K-12 revealed that acquisition of a large amount of foreign DNA has promoted the genetic diversification of E. coli strains. In the emergence of O157: H7, bacteriophages, in particular, played an important role. EHEC are a group of strains with several serotypes, each belonging to different E. coli lineages. Even in an O157 lineage, significant phenotypic and genetic heterogeneities are observed. Recent knowledge on the significance and the generating mechanism of such heterogeneity in EHEC strains are summarized.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number6
Publication statusPublished - Jun 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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