TY - JOUR
T1 - Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse
AU - Lyon, Mary F.
AU - King, Thomas R.
AU - Gondo, Yoichi
AU - Gardner, John M.
AU - Nakatsu, Yoshimichi
AU - Elcher, Eva M.
AU - Brilliant, Murray H.
PY - 1992
Y1 - 1992
N2 - Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
AB - Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
UR - http://www.scopus.com/inward/record.url?scp=0026648110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026648110&partnerID=8YFLogxK
U2 - 10.1073/pnas.89.15.6968
DO - 10.1073/pnas.89.15.6968
M3 - Article
C2 - 1495987
AN - SCOPUS:0026648110
SN - 0027-8424
VL - 89
SP - 6968
EP - 6972
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 15
ER -