Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility

Yoshinori Koga; Hironori Toshima; Hirofumi Nishi; Hirofumi Nishi; Takehiko Sasazuki; Akinori Kimura; Shinji Fukuta; Reizo Kusukawa; Keishiro Kawamura; Yasuharu Nimura; Makoto Nagano; Hisakazu Yasuda; Chuichi Kawai; Tsuneaki Sugimoto; Ryozo Okada; Yoshio Yazaki; Hiromitsu Tanaka; Kenichi Harumi

doi:10.1253/jcj.56.1054

Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility

Yoshinori Koga, Hironori Toshima, Hirofumi Nishi, Hirofumi Nishi, Takehiko Sasazuki, Akinori Kimura, Shinji Fukuta, Reizo Kusukawa, Keishiro Kawamura, Yasuharu Nimura, Makoto Nagano, Hisakazu Yasuda, Chuichi Kawai, Tsuneaki Sugimoto, Ryozo Okada, Yoshio Yazaki, Hiromitsu Tanaka, Kenichi Harumi

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Abstract

To identify genetic factors in the immune system which control the susceptibility to dilated cardiomyopathy (DCM), HLA class II DNA typing was performed in 61 Japanese patients, using PCR/SSO probe analyses. The frequencies of HLA-DQB1∗0503 (15% vs 5%; RR=3.06, X²=7.19) and DQB1∗0604 (21% vs 10%; RR=2.41, X²=6.20) were significantly increased and that of HLA-DQB1∗0502 (RR=1.74) was slightly increased in the DCM patients. The frequency of DQB1∗0303 (16% vs 31%; RR=0.44, X²=5.16) was significantly decreased in the patients. The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQB1 chain. Among the genetic markers studied by Southern blot analyses, IGLV (immunoglobulin lambda light chain, pV3.3) showed a strong association with DCM, i.e. A2/A2 genotype was found in 37.7% of patients whereas it was observed in only 18.9% of the control subjects (RR=2.6, X²=7.77). The frequency of this genotype was higher in patients under age 45 years at the time of diagnosis (45.5%, RR=3.6, X²=10.02). These results suggest that HLA and immunoglobulin genes are closely linked to susceptibility to DCM.

Original language	English
Pages (from-to)	1054-1061
Number of pages	8
Journal	JAPANESE CIRCULATION JOURNAL
Volume	56
Issue number	10
DOIs	https://doi.org/10.1253/jcj.56.1054
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physiology
Cardiology and Cardiovascular Medicine

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Koga, Y., Toshima, H., Nishi, H., Nishi, H., Sasazuki, T., Kimura, A., Fukuta, S., Kusukawa, R., Kawamura, K., Nimura, Y., Nagano, M., Yasuda, H., Kawai, C., Sugimoto, T., Okada, R., Yazaki, Y., Tanaka, H., & Harumi, K. (1992). Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility. JAPANESE CIRCULATION JOURNAL, 56(10), 1054-1061. https://doi.org/10.1253/jcj.56.1054

Koga, Y, Toshima, H, Nishi, H, Nishi, H, Sasazuki, T, Kimura, A, Fukuta, S, Kusukawa, R, Kawamura, K, Nimura, Y, Nagano, M, Yasuda, H, Kawai, C, Sugimoto, T, Okada, R, Yazaki, Y, Tanaka, H & Harumi, K 1992, 'Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility', JAPANESE CIRCULATION JOURNAL, vol. 56, no. 10, pp. 1054-1061. https://doi.org/10.1253/jcj.56.1054

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title = "Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility",

abstract = "To identify genetic factors in the immune system which control the susceptibility to dilated cardiomyopathy (DCM), HLA class II DNA typing was performed in 61 Japanese patients, using PCR/SSO probe analyses. The frequencies of HLA-DQB1∗0503 (15% vs 5%; RR=3.06, X2=7.19) and DQB1∗0604 (21% vs 10%; RR=2.41, X2=6.20) were significantly increased and that of HLA-DQB1∗0502 (RR=1.74) was slightly increased in the DCM patients. The frequency of DQB1∗0303 (16% vs 31%; RR=0.44, X2=5.16) was significantly decreased in the patients. The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQB1 chain. Among the genetic markers studied by Southern blot analyses, IGLV (immunoglobulin lambda light chain, pV3.3) showed a strong association with DCM, i.e. A2/A2 genotype was found in 37.7% of patients whereas it was observed in only 18.9% of the control subjects (RR=2.6, X2=7.77). The frequency of this genotype was higher in patients under age 45 years at the time of diagnosis (45.5%, RR=3.6, X2=10.02). These results suggest that HLA and immunoglobulin genes are closely linked to susceptibility to DCM.",

author = "Yoshinori Koga and Hironori Toshima and Hirofumi Nishi and Hirofumi Nishi and Takehiko Sasazuki and Akinori Kimura and Shinji Fukuta and Reizo Kusukawa and Keishiro Kawamura and Yasuharu Nimura and Makoto Nagano and Hisakazu Yasuda and Chuichi Kawai and Tsuneaki Sugimoto and Ryozo Okada and Yoshio Yazaki and Hiromitsu Tanaka and Kenichi Harumi",

year = "1992",

doi = "10.1253/jcj.56.1054",

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T1 - Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility

AU - Koga, Yoshinori

AU - Toshima, Hironori

AU - Nishi, Hirofumi

AU - Sasazuki, Takehiko

AU - Kimura, Akinori

AU - Fukuta, Shinji

AU - Kusukawa, Reizo

AU - Kawamura, Keishiro

AU - Nimura, Yasuharu

AU - Nagano, Makoto

AU - Yasuda, Hisakazu

AU - Kawai, Chuichi

AU - Sugimoto, Tsuneaki

AU - Okada, Ryozo

AU - Yazaki, Yoshio

AU - Tanaka, Hiromitsu

AU - Harumi, Kenichi

PY - 1992

Y1 - 1992

N2 - To identify genetic factors in the immune system which control the susceptibility to dilated cardiomyopathy (DCM), HLA class II DNA typing was performed in 61 Japanese patients, using PCR/SSO probe analyses. The frequencies of HLA-DQB1∗0503 (15% vs 5%; RR=3.06, X2=7.19) and DQB1∗0604 (21% vs 10%; RR=2.41, X2=6.20) were significantly increased and that of HLA-DQB1∗0502 (RR=1.74) was slightly increased in the DCM patients. The frequency of DQB1∗0303 (16% vs 31%; RR=0.44, X2=5.16) was significantly decreased in the patients. The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQB1 chain. Among the genetic markers studied by Southern blot analyses, IGLV (immunoglobulin lambda light chain, pV3.3) showed a strong association with DCM, i.e. A2/A2 genotype was found in 37.7% of patients whereas it was observed in only 18.9% of the control subjects (RR=2.6, X2=7.77). The frequency of this genotype was higher in patients under age 45 years at the time of diagnosis (45.5%, RR=3.6, X2=10.02). These results suggest that HLA and immunoglobulin genes are closely linked to susceptibility to DCM.

AB - To identify genetic factors in the immune system which control the susceptibility to dilated cardiomyopathy (DCM), HLA class II DNA typing was performed in 61 Japanese patients, using PCR/SSO probe analyses. The frequencies of HLA-DQB1∗0503 (15% vs 5%; RR=3.06, X2=7.19) and DQB1∗0604 (21% vs 10%; RR=2.41, X2=6.20) were significantly increased and that of HLA-DQB1∗0502 (RR=1.74) was slightly increased in the DCM patients. The frequency of DQB1∗0303 (16% vs 31%; RR=0.44, X2=5.16) was significantly decreased in the patients. The increased HLA-DQB1 alleles have a histidine residue in common at the 30th codon for the HLA-DQB1 chain. Among the genetic markers studied by Southern blot analyses, IGLV (immunoglobulin lambda light chain, pV3.3) showed a strong association with DCM, i.e. A2/A2 genotype was found in 37.7% of patients whereas it was observed in only 18.9% of the control subjects (RR=2.6, X2=7.77). The frequency of this genotype was higher in patients under age 45 years at the time of diagnosis (45.5%, RR=3.6, X2=10.02). These results suggest that HLA and immunoglobulin genes are closely linked to susceptibility to DCM.

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ER -

Genetic analysis of dilated cardiomyopathy hla and immunoglobulin genes may confer susceptibility

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