Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Masutaka Furue, Gaku Tsuji, Chikage Mitoma, Takeshi Nakahara, Takahito Chiba, Saori Morino-Koga, Hiroshi Uchi

Research output: Contribution to journalReview articlepeer-review

110 Citations (Scopus)


Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of Dermatological Science
Issue number2
Publication statusPublished - Nov 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology


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