TY - JOUR
T1 - Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma
AU - Kashiwazaki, Haruhiko
AU - Hassan, Nur Mohammad Monsur
AU - Hamada, Jun Ichi
AU - Moriuchi, Tetsuya
AU - Yamazaki, Yutaka
AU - Tei, Kanchu
AU - Totsuka, Yasunori
AU - Inoue, Nobuo
N1 - Funding Information:
Acknowledgments We thank Ms. M. Yanome for help in preparing the manuscript. This work was supported in part by Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2008/7
Y1 - 2008/7
N2 - The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.
AB - The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.
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U2 - 10.1007/s10266-008-0084-1
DO - 10.1007/s10266-008-0084-1
M3 - Article
C2 - 18661203
AN - SCOPUS:48449105484
SN - 1618-1247
VL - 96
SP - 38
EP - 43
JO - Odontology
JF - Odontology
IS - 1
ER -
