Ganoderic acids from ganoderma lucidum: Inhibitory activity of osteoclastic differentiation and structural criteria

Jie Liu; Jun Shiono; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1055/s-0029-1186035

Ganoderic acids from ganoderma lucidum: Inhibitory activity of osteoclastic differentiation and structural criteria

Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.

Original language	English
Pages (from-to)	137-139
Number of pages	3
Journal	Planta medica
Volume	76
Issue number	2
DOIs	https://doi.org/10.1055/s-0029-1186035
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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AU - Kondo, Ryuichiro

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Ganoderic acids from ganoderma lucidum: Inhibitory activity of osteoclastic differentiation and structural criteria

Abstract

All Science Journal Classification (ASJC) codes

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