Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Jie Liu; Jun Shiono; Kuniyoshi Shimizu; Akiko Kukita; Toshio Kukita; Ryuichiro Kondo

doi:10.1016/j.bmcl.2009.02.119

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

Original language	English
Pages (from-to)	2154-2157
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.119
Publication status	Published - Apr 15 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.02.119

Cite this

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abstract = "Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.",

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AU - Liu, Jie

AU - Shiono, Jun

AU - Shimizu, Kuniyoshi

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AU - Kukita, Toshio

AU - Kondo, Ryuichiro

PY - 2009/4/15

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AB - Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

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Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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